The Peptide-binding Cavity Is Essential for Als3-mediated Adhesion of Candida albicans to Human Cells
نویسندگان
چکیده
منابع مشابه
Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells
Candida albicans is the most common cause of hematogenously disseminated and oropharyngeal candidiasis. Both of these diseases are characterized by fungal invasion of host cells. Previously, we have found that C. albicans hyphae invade endothelial cells and oral epithelial cells in vitro by inducing their own endocytosis. Therefore, we set out to identify the fungal surface protein and host cel...
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Adherence of lymphocytes to the fungus is the first step in the direct lymphocyte-mediated antifungal effect against Candida albicans. In this study we identified macrophage-1 antigen (Mac-1) (CD11b/CD18, alpha(M)/beta(2)) as the lymphocyte surface structure responsible for the adhesion of activated lymphocytes to the hyphal form of the fungus. Antibodies specific for epitopes of the alpha-subu...
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Background: The most important virulence factor which plays a central role in Candida albicans pathogenesis is the ability of this yeast to alternate between unicellular yeast and filamentous hyphal forms. Efg1 protein is thought to be the main positive regulating transcription factor, which is responsible for regulating hyphal-specific gene expression under most conditions. ALS3 is one of the ...
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Institute of Dentistry, University of Helsinki, P.O. Box 41, 00014 University of Helsinki, Helsinki Finland Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, P.O. Box 263, 00029 HUS Helsinki, Finland Haartman Institute, Department of Bacteriology and Immunology, University of Helsinki, P.O. Box 21, 00014 University of Helsinki, Helsinki, Finland HUSLAB Clinica...
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Abstract Background and objectives: Candida albicans is a normal flora in skin and mucosa and is not pathogen in normal individuals.The main defence against yeasts ,particulary Candida, is phagocytes, but phagocytesis and opsonization are reduced in thalassemia . the aim of this study was the determination of the frequency of Candida albicans and its species in the oral cavity of patients with ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2014
ISSN: 0021-9258
DOI: 10.1074/jbc.m114.547877